Fable 2 is an excellent choice. One of my favorite games, and I'm not much for RPG's.
I picked up a copy of Ghostbusters for $25 used at a local gamestop. I'm enjoying it far more than I thought I would.
I'd have a hard time picking just one. I think it would be a 3 way tie between Earthbound (SNES), Age of Empires (PC) and Ultima Online (PC). I suppose you could say those are my favorites in their respective genres.
No problems with any of my TT games. I have Lego Indy, Lego Batman, and Lego Star Wars - The complete Saga.
Only trouble I have is now and then I'll somehow jump myself into a spot that I can't get out of and have to restart the game. But it happens very few and far between.