Just started playing this yesterday and I am somewhat enjoying it. It has a good overall feel to the game, going for that Fallout 3 sort-of-feel. I think the fighting engine is a bit buggy and not fluid or easy enough to use. But I have only played the game for 2 hours 8).
I haven't played it yet but from my buddies that have got it they say its like Resident Evil meets Fallout 3. To me that sounds pretty sweet! Going to be getting it soon!