Best PC configuration? It depends on what you're looking to get into specifically, whether it's video game design or simply logo/banner design, but you should definitely look at systems made to run resource-heavy applications, such as Gaming PCs. You're basically looking at something with a High Clock Quad core CPU, 6+GB of RAM, dedicated video cards, and fast spinning SATA disks/RAID arrays.
It depends specifically what is needed, but it never hurts to go higher in specs than what is needed for the job. I've told people that they never really know how much they'll need, and overall in the long run, it's cheaper to go the more expensive route (as in, get very fast hardware off the bat) and then upgrade, rather than to cheap out and have to deal with upgrading in the future.