High Performance with a bunch of tweaks on both my laptop and desktop. Desktop is obviously made to be a high performance machine, and is used for more than running games. Basically, don't need any power saving options reducing performance of it despite it being on 24/7 under load (Folding@Home, 3x GPU and 1x SMB 64-bits). I do however have the GPUs and the CPU throttling back clocks (and even shutting off idle cores, since it's an i7 machine) when they are under low load or are idle for the sake of power, so it isn't a 100% clock power eating machine when it's not doing anything.
The laptop is ran on a custom profile that mirrors the High Performance Profile. Cooling is set to Active for both Battery and AC. Integrated Video will throttle to Battery Saving mode, which is enough to accelerate 1080p video and run Aero, but when games fire up it'll kick itself back into Maximum Performance. The CPU is set to the same defaults as the High Performance, which is lowest CPU running state when idle and maximum state (in clocks) when loaded for the sake of things, but if I know I'm going to be needing battery for a very, very long time I'll switch the CPU to run at lower clocks when under full load. Wireless is always at Maximum Performance since I always seem to be connected in the worst of spots (which is generally through a lot of thick walls at the edge of the access point's range). Ethernet Adapter uses a mode that turns it on and off every 30 seconds to check for a link. It will remain on and at full speed if it's linked up but otherwise will remain off. Wireless when it's not connected will scan once every few minutes but will otherwise turn off the radio.