First impression is that it is well designed with a good use of colours that work well together. In terms of the layout of the page,I agree with Alex_Mac, as the columns to the right of the articles is almost as wide as the articles themselves, my suggestion here would be to cut it down to just one column and give the articles some more space. I would also say you have a couple too many ads on your site, cutting it down to two or three shouldn't change your revenue much but will be a lot nicer for your users.
Other than that there are just a couple of issues:
1. There appears to be a non-loading image in the top of the header.
2. Your RSS icon barely show up against the orange header, so either move it elsewhere or change its colour a bit.
@Kowsari: I recommend you go see a doctor about that, that could be a serious health issue you have there.